Progesterone and preterm birth prevention: translating clinical trials data into clinical practice

0002-9378/free © 2012 Published by Mosby, Inc. OBJECTIVE: We sought to provide evidenc the prevention of preterm birth (PTB). METHODS: Relevant documents, in part PubMed (US National Library of Medicine, 19 in English, which evaluate the effectiveness o gens evaluated were, in particular, vaginal pr caproate. Additionally, the Cochrane Library, through review of the above were utilized to according to population studied, with separa prior PTB, or short transvaginal ultrasound c factors. Consistent with US Preventive Task F quality based on the highest level of evidence RESULTS AND RECOMMENDATIONS: S women with singleton gestations, no prior PTB progesterone, either 90-mg gel or 200-mg su perinatal morbidity and mortality, and can be screening of singleton gestations without prior of debate. CL screening in singleton gestatio mandated. Nonetheless, implementation of s sonable, and can be considered by individua gleton gestations with prior PTB 20-36 6/7 w 250 mg intramuscularly weekly, preferably st mended. In these women with prior PTB, if the at 24 weeks, cervical cerclage may be offer prevention of PTB in women who have in the labor, or preterm premature rupture of mem mend the use of progestogens in women with